The cardiac device related infective endocarditis (CDRIE) is an important indication for the implantable cardiac device extraction. In patients after recovery from CDRIE, who present indication for implantable cardioverter-defibrilator (ICD) but without necessity for pacing therapy the subcutaneous ICD (S-ICD) seems to be a reasonable alternative. Here we present a patient with CRT-D device transferred to our hospital with the diagnosis of CDRIE and many comorbidities. The patient presented increased inflammatory markers serum level during the entire period of hospitalization, after device explanation and termination of antibiotic therapy. The blood culture tests were negative and transesophageal echocardiography showed no sign of endocarditis, therefore despite inflammatory biomarkers the patient has been implanted with S-ICD.